3. Disruption of gut microbiota: The gut microbiota plays a crucial role in our body's internal environment. Its stability is essential for proper nutrient absorption, maintaining normal immunity, and protecting liver health, among other functions. Long-term and high doses of oral amoxicillin or other antibiotics, mostly broad-spectrum, not only kill harmful bacteria but also affect and suppress beneficial gut bacteria. Even if they don't eliminate them entirely, they gradually disrupt the balance and activity of gut microbiota, leading to dysbiosis. There is a condition called antibiotic-associated diarrhea, caused by long-term antibiotic use, where the gut microbiota imbalance leads to diarrhea. This is a mild consequence; typically, the gut flora can recover after stopping the antibiotics. However, if there's long-term misuse leading to irreparable damage to the gut microbiota, the consequences can be severe and irreversible.